Equine major histocompatibility complex class I molecules act as entry receptors that bind to equine herpesvirus-1 glycoprotein D

@inproceedings{Sasaki2011EquineMH,
  title={Equine major histocompatibility complex class I molecules act as entry receptors that bind to equine herpesvirus-1 glycoprotein D},
  author={Michihito Sasaki and Rie Hasebe and Yoshinori Makino and Tadaki Suzuki and Hideto Fukushi and Minoru Okamoto and Kazuya Matsuda and Hiroyuki Taniyama and H Sawa and Takashi Kimura},
  booktitle={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2011}
}
The endotheliotropism of equine herpesvirus-1 (EHV-1) leads to encephalomyelitis secondary to vasculitis and thrombosis in the infected horse central nervous system (CNS). To identify the host factors involved in EHV-1 infection of CNS endothelial cells, we performed functional cloning using an equine brain microvascular endothelial cell cDNA library. Exogenous expression of equine major histocompatibility complex (MHC) class I heavy chain genes conferred susceptibility to EHV-1 infection in… CONTINUE READING
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Genes to Cells

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