Equine luteal function regulation may depend on the interaction between cytokines and vascular endothelial growth factor: an in vitro study.

@article{Galvo2012EquineLF,
  title={Equine luteal function regulation may depend on the interaction between cytokines and vascular endothelial growth factor: an in vitro study.},
  author={Ant{\'o}nio Miguel Galv{\~a}o and Sofia Teives Henriques and Daria Pestka and Karolina Lukasik and Dariusz Skarżyński and Luisa Mateus and Graça Maria Leitao Ferreira-Dias},
  journal={Biology of reproduction},
  year={2012},
  volume={86 6},
  pages={187}
}
We hypothesized that cytokines influence luteal angiogenesis in mares, while angiogenic factors themselves can also regulate luteal secretory capacity. Therefore, the purpose of this study was to evaluate the role of cytokines--tumor necrosis factor alpha (TNF), interferon gamma (IFNG) and Fas ligand (FASL)--on in vitro modulation of angiogenic activity and mRNA level of vascular endothelial growth factor A (VEGF), its receptor VEGFR2, thrombospondin 1 (TSP1), and its receptor CD36 in equine… CONTINUE READING
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