Equine infectious anemia viral vector-mediated codelivery of endostatin and angiostatin driven by retinal pigmented epithelium-specific VMD2 promoter inhibits choroidal neovascularization.

@article{Kachi2009EquineIA,
  title={Equine infectious anemia viral vector-mediated codelivery of endostatin and angiostatin driven by retinal pigmented epithelium-specific VMD2 promoter inhibits choroidal neovascularization.},
  author={Shu Kachi and Katie Binley and Katsutoshi Yokoi and Naoyasu Umeda and Hideo Akiyama and Daisuke Muramatu and Sharifah Iqball and On Kan and Stuart W. Naylor and Peter Anthony Campochiaro},
  journal={Human gene therapy},
  year={2009},
  volume={20 1},
  pages={31-9}
}
Equine infectious anemia virus (EIAV) is a nonprimate lentivirus that does not cause human disease. Subretinal injection into mice of a recombinant EIAV lentiviral vector in which lacZ is driven by a CMV promoter (EIAV CMV LacZ) resulted in rapid and strong expression of LacZ in retinal pigmented epithelial (RPE) cells and some other cells including ganglion cells, resulting in the presence of 5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside within the optic nerve. Substitution of the RPE… CONTINUE READING
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Regression of ocular neovascularization by increased expression of pigment epitheliumderived factor

  • K. Mori, P. Gehlbach, A. Ando, D. McVey, L. Wei, P. A. Campochiaro
  • Invest. Ophthalmol. Vis. Sci
  • 2001
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