Equine herpesvirus type 1 (EHV-1) utilizes microtubules, dynein, and ROCK1 to productively infect cells.

@article{Frampton2010EquineHT,
  title={Equine herpesvirus type 1 (EHV-1) utilizes microtubules, dynein, and ROCK1 to productively infect cells.},
  author={Arthur R. Frampton and Hiroaki Uchida and Jens von Einem and William F. Goins and Paola Grandi and Justus B Cohen and Nikolaus Osterrieder and Joseph Charles Glorioso},
  journal={Veterinary microbiology},
  year={2010},
  volume={141 1-2},
  pages={12-21}
}
To initiate infection, equine herpesvirus type 1 (EHV-1) attaches to heparan sulfate on cell surfaces and then interacts with a putative glycoprotein D receptor(s). After attachment, virus entry occurs either by direct fusion of the virus envelope with the plasma membrane or via endocytosis followed by fusion between the virus envelope and an endosomal membrane. Upon fusion, de-enveloped virus particles are deposited into the cytoplasm and travel to the nucleus for viral replication. In this… CONTINUE READING