Equine alphaherpesviruses (EHV-1 and EHV-4) differ in their efficiency to infect mononuclear cells during early steps of infection in nasal mucosal explants.

@article{Vandekerckhove2011EquineA,
  title={Equine alphaherpesviruses (EHV-1 and EHV-4) differ in their efficiency to infect mononuclear cells during early steps of infection in nasal mucosal explants.},
  author={Annelies P. Vandekerckhove and Sarah Glorieux and Annick C Gryspeerdt and Lennert Steukers and Jan Van Doorsselaere and Nikolaus Osterrieder and Gerlinde R. Van de Walle and Hans Nauwynck},
  journal={Veterinary microbiology},
  year={2011},
  volume={152 1-2},
  pages={21-8}
}
Equine herpesvirus type 1 (EHV-1) replicates extensively in the epithelium of the upper respiratory tract, after which it can spread throughout the body via a cell-associated viremia in mononuclear leukocytes reaching the pregnant uterus and central nervous system. In a previous study, we were able to mimic the in vivo situation in an in vitro respiratory mucosal explant system. A plaquewise spread of EHV-1 was observed in the epithelial cells, whereas in the connective tissue below the… CONTINUE READING