Equine TIMP-1 and TIMP-2: identification, activity and cellular sources.

@article{Clegg1998EquineTA,
  title={Equine TIMP-1 and TIMP-2: identification, activity and cellular sources.},
  author={Peter David Clegg and Anne Coughlan and Stuart D. Carter},
  journal={Equine veterinary journal},
  year={1998},
  volume={30 5},
  pages={416-23}
}
Matrix metalloproteinases (MMPs) are the main enzymes involved in connective tissue turnover. Regulation of MMPs is achieved by controlling production, activation of the pro-enzymes together with the presence of inhibitors, such as, tissue inhibitors of metalloproteinases (TIMPS). The presence of TIMPs in equine synovial fluid was assessed by the ability of the fluid to inhibit equine MMP-9 activity using a gelatin degradation ELISA. The cellular source of the TIMPs was determined using culture… CONTINUE READING