Equilibrium under inbreeding in balanced polymorphisms.

  title={Equilibrium under inbreeding in balanced polymorphisms.},
  author={Italo Barrai and Siegfried Mandel},
  journal={Bulletin of the World Health Organization},
  volume={45 2},
The results of a study on frequencies of genes causing lethal or sublethal disease are reported in relation to the level of consanguinity and heterozygote advantage in populations. The theoretical background of the population dynamics of genes under heterozygote advantage and in the presence of inbreeding is examined and the theoretical models are applied to the estimation of the level of heterosis for lethal and sublethal genes that are responsible for important public health problems in… CONTINUE READING