Equilibrium study of protein denaturation by urea.

Abstract

Though urea is commonly used to denature proteins, the molecular mechanism of its denaturing ability is still a subject of considerable debate. Previous molecular dynamics simulation studies have sought to elucidate the mechanism of urea denaturation by focusing on the pathway of denaturation rather than examining the effect of urea on the folding/unfolding… (More)
DOI: 10.1021/ja909348c

Topics

10 Figures and Tables

Cite this paper

@article{Canchi2010EquilibriumSO, title={Equilibrium study of protein denaturation by urea.}, author={Deepak R Canchi and Dietmar Paschek and Angel E. Garc{\'i}a}, journal={Journal of the American Chemical Society}, year={2010}, volume={132 7}, pages={2338-44} }