Equilibrium Reaction Rates and the Mechanisms of Bovine Heart and Rabbit Muscle Lactate Dehydrogenases.

@article{Silverstein1964EquilibriumRR,
  title={Equilibrium Reaction Rates and the Mechanisms of Bovine Heart and Rabbit Muscle Lactate Dehydrogenases.},
  author={E. Silverstein and Paul Boyer},
  journal={The Journal of biological chemistry},
  year={1964},
  volume={239},
  pages={3901-7}
}
Almost all enzyme kinetic studies have been based on measurement of net chemical reaction. Isotopic tracer techniques make possible other types of kinetic measurements, including the rate of interconversion of reactants or interchange of atoms between substrates at equilibrium.1 Only very limited studies have been reported of such equilibrium rate measurements with known concentrations of all reactants (l-5). Studies by Boyer, Mills, and Fromm (4) and by Graves and Boyer (5) of the glutamine… CONTINUE READING