# Equilibria and stability of a class of positive feedback loops

@article{LopezCaamal2014EquilibriaAS,
title={Equilibria and stability of a class of positive feedback loops},
author={F. Lopez-Caamal and R. Middleton and H. Huber},
journal={Journal of Mathematical Biology},
year={2014},
volume={68},
pages={609-645}
}
• Published 2014
• Physics, Medicine
• Journal of Mathematical Biology
• Positive feedback loops are common regulatory elements in metabolic and protein signalling pathways. The length of such feedback loops determines stability and sensitivity to network perturbations. Here we provide a mathematical analysis of arbitrary length positive feedback loops with protein production and degradation. These loops serve as an abstraction of typical regulation patterns in protein signalling pathways. We first perform a steady state analysis and, independently of the chain… CONTINUE READING
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