Equid herpesvirus type-1 exhibits neurotropism and neurovirulence in a mouse model.

@article{Mori2012EquidHT,
  title={Equid herpesvirus type-1 exhibits neurotropism and neurovirulence in a mouse model.},
  author={Cl{\'a}udia Madalena Cabrera Mori and Enio Mori and L{\'e}ia Cec{\'i}lia de Lima F{\'a}varo and Claudio R. Mirasso Santos and M. C. C. S. H. Lara and Eliana Monteforte Cassaro Villalobos and Elenice Maria Sequetin Cunha and P. E. Brand{\~a}o and Leonardo Jos{\'e} Richtzenhain and Paulo C{\'e}sar Maiorka},
  journal={Journal of comparative pathology},
  year={2012},
  volume={146 2-3},
  pages={202-10}
}
Intranasal inoculation of equid herpesvirus type-1 (EHV-1) Brazilian strains A4/72 and A9/92 induced an acute and lethal infection in four different inbred mouse strains. Clinical and neurological signs appeared between the 2nd and 3rd day post inoculation (dpi) and included weight loss, ruffled fur, a hunched posture, crouching in corners, nasal and ocular discharges, dyspnoea, dehydration and increased salivation. These signs were followed by increased reactivity to external stimulation… CONTINUE READING

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