Equations and calculations for fermentations of butyric acid bacteria

@article{Papoutsakis1984EquationsAC,
  title={Equations and calculations for fermentations of butyric acid bacteria},
  author={Eleftherios Terry Papoutsakis},
  journal={Biotechnology and Bioengineering},
  year={1984},
  volume={26}
}
  • E. Papoutsakis
  • Published 1 February 1984
  • Chemistry
  • Biotechnology and Bioengineering
A stoichiometric equation has been derived which describes the interrelations among the various products and biomass in fermentations of butyric acid bacteria. The derivation of the equation is based on an assumed ATP yield, two biological regularities, and the biochemistry of product formation of the fermentations. The equation obeys the constraints imposed on growth and product formation by thermodynamics and the biochemical topology. The validity of the equation is tested using a variety of… 
Equations and calculations of product yields and preferred pathways for butanediol and mixed‐acid fermentations
TLDR
Fermentation (stoichiometric) equations are derived for anaerobic saccharolytic fermentations of butanediol and mixed acids and it is shown that the equations are useful for checking the consistency of experimental data, for calculating maximal yields and selectivities for the fermentation products, and calculating the extent of utilization of the Embden–Meyerhof–Parnas pathway versus the Hexose Monophosphate pathway of glucose utilization.
Fermentation equations for propionic‐acid bacteria and production of assorted oxychemicals from various sugars
TLDR
The equations for anaerobic fermentations of propionic‐acid bacteria and for production of various oxychemicals from pentoses, hexoses, and cellobiose are shown to be valuable for calculating maximal yields and selectivities of the various fermentation products and as “gateway sensors” for monitoring of the fermentations.
Stoichiometric modeling of Clostridium acetobutylicum fermentations with non-linear constraints.
The use of stoichiometric relations for the description and analysis of microbial cultures
TLDR
A general method is described, which enables the derivation of predictive fermentation equations for any microbiological process using the key intermediates concept and is fully illustrated for the very simple example of heterotrophic growth on a single substrate without product formation.
Kinetic Study of Acetone-Butanol-Ethanol Fermentation in Continuous Culture
TLDR
A kinetic model is used for elucidating the behavior of the ABE fermentation under the conditions that are most relevant to continuous cultures and provides guidance for future metabolic engineering and fermentation optimization studies.
Continuous and biomass recycle fermentations of Clostridium acetobutylicum
TLDR
The effect of biomass recycle at a variety of dilution rates and recycle ratios under both glucose and non-glucose limited conditions on product yields and selectivities has been investigated.
Mathematical modelling of clostridial acetone-butanol-ethanol fermentation
TLDR
This review discusses mathematical models employed to elucidate the complex interlinked regulation and conditions that determine these two distinct metabolic states and govern the transition between them, with a focus on the mechanisms controlling intra- and extracellular changes between acidogenesis and solventogenesis.
Mathematical models of ABE fermentation: review and analysis
TLDR
This article has reviewed the literature published in the area of mathematical modeling of the ABE fermentation and tried to present an analysis of these models in terms of their potency in describing the overall physiology of the process, design features, mode of operation and other additional features.
NADH fluorescence in a fed batch fermentation by C. acetobutylicum
TLDR
The existing process kinetics model of the acetone-butanol fermentation was adjusted and adapted for the fed-batch mode of operation and the characterisation of the culture physiological state under dynamic growth conditions was attempted by utilizing on-line fluorescence measurements and the concept of stoichiometric metabolic pathway rates.
Determination of biomass yield for growth of Candida utilis on glucose: Black box and metabolic descriptions
TLDR
A methodology to establish the stoichiometric relations in microbial processes is shown and the biomass yield is calculated for the Candida utilis–glucose system by using two types of system descriptions found in the literature, the black box model and metabolic description.
...
...

References

SHOWING 1-10 OF 36 REFERENCES
Feasible improvements of the butanol production by Clostridium acetobutylicum.
TLDR
With the increasing availability of low-cost petrochemical raw materials and the growth of the chemical industries the fermentation process became uneconomical in industrialized countries and was discontinued.
Acetone and Butanol Production by Clostridium acetobutylicum in a Synthetic Medium
The effect of the component concentrations of a synthetic medium on acetone and butanol fermentation by Clostridium acetobutylicum ATCC 824 was investigated. Cell growth was dependent on the presence
The Prediction of Growth Yields in Methylotrophs
TLDR
For the majority of methylotrophs the growth yield is determined by NAD(P)H supply as well as ATP supply, and for some methylotphs growth yields may be exclusively NAD( P)H-limited, the concept of Y ATP in methylotophs should be used with extreme caution.
Production of Feedstock Chemicals
TLDR
Renewable raw materials may be converted by biological means to feedstocks for the chemical industry, although advances may enable the use of less expensive lignocellulosic materals.
Biomass as a source of chemical feedstocks: an economic evaluation.
It is suggested that the raw materials and technology exist for basing a major fraction of the U.S. chemical industry on four fermentation products, used in the proper portions: ethanol, isopropanol,
Trends in the Biology of Fermentations for Fuels and Chemicals
TLDR
Fermentation Science: Basic and Applied Research Needs and Poster Abstracts.
Acetoacetate decarboxylase. Preparation of the enzyme.
TLDR
Crystalline acetoacetate decarboxylase can be prepared from Clostridium acetobutylicum by the following steps: Preparation of an acetone powder from the bacteria, extraction of this powder at pH 5.9, precipitation of the enzyme at pH 3.8, and chromatography over diethylaminoethylcellulose, followed by crystallization.
BIOCHEMICAL PRODUCTION OF INDUSTRIAL SOLVENTS (ACETONE‐BUTANOL‐ETHANOL) FROM RENEWABLE RESOURCES
Since 1973, the price of oil has increased from $3.60 (U.S.) per barrel to $27 to $40 (U.S.)* per barrel, depending on the supplier. In 1979 alone, prices have increased an average of 35% and further
Biological Formation of Molecular Hydrogen
TLDR
It is assumed that the original pattern of reactions leading to H2 production has become modified in various ways during the course of biochemical evolution, and this point of view suggests profitable approaches for clarifying a number of problems in the intermediary metabolism of microorganisms which produce or utilize H2.
...
...