Equal sister chromatid exchange is a major mechanism of double-strand break repair in yeast.

@article{GonzlezBarrera2003EqualSC,
  title={Equal sister chromatid exchange is a major mechanism of double-strand break repair in yeast.},
  author={Sergio Gonz{\'a}lez-Barrera and Felipe Cort{\'e}s-Ledesma and Ralf Erik Wellinger and Andr{\'e}s Aguilera},
  journal={Molecular cell},
  year={2003},
  volume={11 6},
  pages={1661-71}
}
Equal sister chromatid exchange (SCE) has been thought to be an important mechanism of double-strand break (DSB) repair in eukaryotes, but this has never been proven due to the difficulty of distinguishing SCE products from parental molecules. To evaluate the biological relevance of equal SCE in DSB repair and to understand the underlying molecular mechanism, we developed recombination substrates for the analysis of DSB repair by SCE in yeast. In these substrates, most breaks are limited to one… CONTINUE READING

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