Epstein-Barr virus with the latent infection nuclear antigen 3B completely deleted is still competent for B-cell growth transformation in vitro.

@article{Chen2005EpsteinBarrVW,
  title={Epstein-Barr virus with the latent infection nuclear antigen 3B completely deleted is still competent for B-cell growth transformation in vitro.},
  author={Adrienne Chen and Matthew Divisconte and Xiaoqun Jiang and Carol Quink and Fred Wang},
  journal={Journal of virology},
  year={2005},
  volume={79 7},
  pages={4506-9}
}
The Epstein-Barr virus (EBV) nuclear antigen 3B (EBNA-3B) is considered nonessential for EBV-mediated B-cell growth transformation in vitro based on three virus isolates with EBNA-3B mutations. Two of these isolates could potentially express truncated EBNA-3B products, and, similarly, we now show that the third isolate, IB4, has a point mutation and in-frame deletion of 263 amino acids. In order to test whether a virus with EBNA-3B completely deleted can immortalize B-cell growth, we first… CONTINUE READING
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