Epstein-Barr virus-transformed lymphocytes produce monoclonal autoantibodies that react with antigens in multiple organs.

@article{Garzelli1984EpsteinBarrVL,
  title={Epstein-Barr virus-transformed lymphocytes produce monoclonal autoantibodies that react with antigens in multiple organs.},
  author={Carlo Garzelli and F. E. Taub and Josh Scharff and Bellur S Prabhakar and Fredda V Ginsberg-Fellner and Abner Louis Notkins},
  journal={Journal of virology},
  year={1984},
  volume={52 2},
  pages={722-5}
}
Peripheral blood lymphocytes from normal individuals and patients with autoimmune abnormalities such as insulin-dependent diabetes mellitus and thyroiditis were infected with Epstein-Barr virus, and the culture supernatants were tested for autoantibodies that reacted with normal tissues. Between 58 and 86% of Epstein-Barr virus-transformed cultures produced immunoglobulin M antibodies, and between 9 and 24% of the transformed cultures produced immunoglobulin G antibodies that reacted with… CONTINUE READING

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