Epstein-Barr virus transcription activator R upregulates BARF1 expression by direct binding to its promoter, independent of methylation.

@article{Hoebe2012EpsteinBarrVT,
  title={Epstein-Barr virus transcription activator R upregulates BARF1 expression by direct binding to its promoter, independent of methylation.},
  author={Eveline K Hoebe and Christoph Wille and Erik S Hopmans and Amanda R. Robinson and Jaap M Middeldorp and Shannon C. Kenney and Astrid E. Greijer},
  journal={Journal of virology},
  year={2012},
  volume={86 20},
  pages={11322-32}
}
Epstein-Barr virus (EBV) BamHI-A rightward frame 1 (BARF1) is considered a major viral oncogene in epithelial cells and has immune-modulating properties. However, in B cells and lymphomas, BARF1 expression is restricted to the viral lytic replication cycle. In this report, the transcriptional regulation of BARF1 during lytic replication is unraveled. Bisulfite sequencing of various cell lines indicated a high level of methylation of the BARF1 gene control region. A BARF1 promoter luciferase… CONTINUE READING
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