Epstein-Barr virus superinduces a new human B cell differentiation antigen (B-LAST 1) expressed on transformed lymphoblasts.

@article{ThorleyLawson1982EpsteinBarrVS,
  title={Epstein-Barr virus superinduces a new human B cell differentiation antigen (B-LAST 1) expressed on transformed lymphoblasts.},
  author={David Thorley-Lawson and Robert Turner Schooley and Atul K. Bhan and Lee M. Nadler},
  journal={Cell},
  year={1982},
  volume={30 2},
  pages={415-25}
}
We have developed a monoclonal antibody that detects the first human B-cell-specific differentiation antigen expressed on transformed B lymphoblasts. The antigen is termed B-LAST 1 and is found on B cells transformed in vitro with Epstein-Barr virus (EBV) and pokeweed mitogen; in vivo with EBV and antigen; and on neoplastic B cells from chronic lymphocytic leukemia and poorly differentiated lymphoma. The antigen has a molecular weight of 45,000 and was not found on cells of T, null or myeloid… CONTINUE READING

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