Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy.

@article{Rossig2002EpsteinBarrVH,
  title={Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy.},
  author={Claudia Rossig and Catherine M. Bollard and Jed G. Nuchtern and Cliona M Rooney and Malcolm K. Brenner},
  journal={Blood},
  year={2002},
  volume={99 6},
  pages={2009-16}
}
Primary T cells expressing chimeric receptors specific for tumor or viral antigens have considerable therapeutic potential. Unfortunately, their clinical value is limited by their rapid loss of function and failure to expand in vivo, presumably due to the lack of costimulator molecules on tumor cells and the inherent limitations of signaling exclusively through the chimeric receptor. Epstein-Barr virus (EBV) infection of B lymphocytes is near universal in humans and stimulates high levels of… CONTINUE READING