Epstein-Barr virus-specific cytotoxic T-cell recognition of transfectants expressing the virus-coded latent membrane protein LMP.

@article{Murray1988EpsteinBarrVC,
  title={Epstein-Barr virus-specific cytotoxic T-cell recognition of transfectants expressing the virus-coded latent membrane protein LMP.},
  author={R J Murray and Denan Wang and Lawrence S Young and Fred Wang and Martin Rowe and Elliott Kieff and Alan B. Rickinson},
  journal={Journal of virology},
  year={1988},
  volume={62 10},
  pages={3747-55}
}
Cytotoxic T cells from Epstein-Barr virus (EBV)-immune individuals specifically kill EBV-transformed B cells from HLA class I antigen-matched donors even though the latently infected cells express only a restricted set of virus genes. The virus-induced target antigens recognized by these immune T cells have not been identified. In our experiments, EBV DNA sequences encoding the virus latent gene products Epstein-Barr nuclear antigen (EBNA)1, EBNA 2, and EBNA-LP and the latent membrane protein… CONTINUE READING