Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation.

@article{Cohen1991EpsteinBarrVN,
  title={Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation.},
  author={Jeffrey I. Cohen and Fred Wang and Elliott Kieff},
  journal={Journal of virology},
  year={1991},
  volume={65 5},
  pages={2545-54}
}
Epstein-Barr virus (EBV) nuclear protein 2 (EBNA-2) is essential for B-lymphocyte growth transformation. EBNA-2 transactivates expression of the EBV latent membrane protein (LMP-1) and also transactivates expression of the B-lymphocyte proteins CD21 and CD23. In order to analyze the functional domains of EBNA-2, we constructed 11 linker-insertion and 15 deletion mutations. Each of the mutant EBNA-2 proteins localized to the nucleus, and each was expressed at levels similar to wild-type EBNA-2… CONTINUE READING

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