Epstein-Barr virus nuclear antigen 2 disrupts mitotic checkpoint and causes chromosomal instability.

@article{Pan2009EpsteinBarrVN,
  title={Epstein-Barr virus nuclear antigen 2 disrupts mitotic checkpoint and causes chromosomal instability.},
  author={Shih-Hsuan Pan and Chia-Ching Tai and C S Lin and Wei-Bin Hsu and Shu-Fan Chou and Chih-Chang Lai and J Chen and H. -F. Tien and F Lee and W Y Wang},
  journal={Carcinogenesis},
  year={2009},
  volume={30 2},
  pages={366-75}
}
The Epstein-Barr virus nuclear antigen 2 (EBNA2) plays a key role in transformation of B-lymphocytes mediated by Epstein-Barr virus (EBV) and can induce tumor formation in transgenic mice. However, the precise mechanism underlying EBNA2-mediated tumorigenesis remains elusive. Here, we report that EBNA2 can compromise mitotic spindle checkpoint (MSC) induced by the spindle inhibitor nocodazole and cause chromosomal instability (CIN) in HEp-2, U2-OS and BJAB cells. When EBNA2-expressing cells… CONTINUE READING
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SV 40 T / tcommon polypeptide specifically induces apoptosis in human cancer cells that overexpress HER 2

  • H. F. Tien
  • Cancer Res .
  • 2006

Decoding the links between mitosis , cancer , and chemotherapy : the mitotic checkpoint , adaptation , and cell death

  • S. Kotani
  • Cancer Cell
  • 2005

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