Epstein-Barr virus nuclear antigen 1 is a DNA-binding protein with strong RNA-binding activity.

@article{Lu2004EpsteinBarrVN,
  title={Epstein-Barr virus nuclear antigen 1 is a DNA-binding protein with strong RNA-binding activity.},
  author={Chih-Chung Lu and Chia-wei Wu and Shin C Chang and Tzu-Yi Chen and Chwan-Ren Hu and Ming-Yi Yeh and J. S. Chen and Mei-Ru Chen},
  journal={The Journal of general virology},
  year={2004},
  volume={85 Pt 10},
  pages={
          2755-65
        }
}
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1) plays key roles in both the regulation of gene expression and the replication of the EBV genome in latently infected cells. To characterize the RNA-binding activity of EBNA-1, it was demonstrated that EBNA-1 binds efficiently to RNA homopolymers that are composed of poly(G) and weakly to those composed of poly(U). All three RGG boxes of EBNA-1 contributed additively to poly(G)-binding activity and could mediate RNA binding when attached to a… CONTINUE READING

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