Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment.

@article{Kudoh2005EpsteinBarrVL,
  title={Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment.},
  author={Ayumi Kudoh and Masatoshi Fujita and Lumin Zhang and Noriko Shirata and Tohru Daikoku and Yutaka Sugaya and Hiroki Isomura and Yukihiro Nishiyama and Tatsuya Tsurumi},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 9},
  pages={8156-63}
}
When exposed to genotoxic stress, eukaryotic cells demonstrate a DNA damage response with delay or arrest of cell-cycle progression, providing time for DNA repair. Induction of the Epstein-Barr virus (EBV) lytic program elicited a cellular DNA damage response, with activation of the ataxia telangiectasia-mutated (ATM) signal transduction pathway. Activation of the ATM-Rad3-related (ATR) replication checkpoint pathway, in contrast, was minimal. The DNA damage sensor Mre11-Rad50-Nbs1 (MRN… CONTINUE READING
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