• Medicine
  • Published in
    Molecular and cellular…
    2004

Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha.

@article{Wakisaka2004EpsteinBarrVL,
  title={Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha.},
  author={Naohiro Wakisaka and Satoru Kondo and Tomokazu Yoshizaki and Shigeyuki Murono and Mitsuru Furukawa and Joseph S. Pagano},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 12},
  pages={
          5223-34
        }
}
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription factor composed of HIF-1 alpha and HIF-1 beta that is the central regulator of responses to hypoxia. The specific binding of HIF-1 to the hypoxia-responsive element (HRE) induces the transcription of genes that respond to hypoxic conditions, including vascular endothelial growth factor (VEGF). Here we report that expression of HIF-1 alpha is increased in diverse Epstein-Barr virus (EBV)-infected type II… CONTINUE READING

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