Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation.

@article{Luftig2004EpsteinBarrVL,
  title={Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation.},
  author={Micah A Luftig and Teruhito Yasui and Vishal Soni and M S Kang and Nils G. Jacobson and Ellen Cahir-McFarland and Brian Seed and Elliott Kieff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 1},
  pages={141-6}
}
Epstein-Barr virus (EBV) latent infection membrane protein 1 (LMP1)-induced NF-kappaB activation is important for infected cell survival. LMP1 activates NF-kappaB, in part, by engaging tumor necrosis factor (TNF) receptor-associated factors (TRAFs), which also mediate NF-kappaB activation from LTbetaR and CD40. LTbetaR and CD40 activation of p100/NF-kappaB2 is now known to be NIK/IKKalpha-dependent and IKKbeta/IKKgamma independent. In the experiments described here, we found that EBV LMP1… CONTINUE READING
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