Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1.

@article{Vaughan1995EpsteinBarrVA,
  title={Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1.},
  author={John H. Vaughan and Jean R. Valbracht and Minh Dang Nguyen and Handley Handley and Richard S. Smith and Kara Patrick and Gary H Rhodes},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={95 3},
  pages={1306-15}
}
In previous studies of infectious mononucleosis, we found IgM autoantibodies which react with hematopoietic cell antigens. Many of these were inhibited by synthetic glycine/alanine peptides representing the glycine/alanine repeat of Epstein-Barr virus nuclear antigen-1. We have cloned and expressed fragments of genes encoding two of these autoantigens. One gene (p542) encodes a protein containing a glycine-rich 28-mer, which is its chief autoantigenic epitope and which represents a newly… CONTINUE READING
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