Epstein-Barr virus in gastric adenocarcinomas: association with ethnicity and CDKN2A promoter methylation.

@article{Vo2002EpsteinBarrVI,
  title={Epstein-Barr virus in gastric adenocarcinomas: association with ethnicity and CDKN2A promoter methylation.},
  author={Quynh N Vo and Jseph Geradts and Margaret L Gulley and Donald A. Boudreau and J. Cervera Bravo and Barbara G. Schneider},
  journal={Journal of clinical pathology},
  year={2002},
  volume={55 9},
  pages={669-75}
}
AIMS It has been shown previously (by immunohistochemistry) that gastric adenocarcinomas harbouring Epstein-Barr virus (EBV) frequently lose p16 protein. This study aimed to examine the mechanisms of inactivation of the CDKN2A gene and correlate the results with clinicopathological features. METHODS Methylation specific polymerase chain reaction was used to detect CDKN2A promoter methylation in gastric adenocarcinomas from American patients. In addition, immunohistochemistry was used to… CONTINUE READING
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