Epstein-Barr virus immortalization of normal cells of B cell lineage with nonproductive, rearranged immunoglobulin genes.

@article{Tosato1986EpsteinBarrVI,
  title={Epstein-Barr virus immortalization of normal cells of B cell lineage with nonproductive, rearranged immunoglobulin genes.},
  author={Giovanna Tosato and Gerald E. Marti and Robert Yarchoan and Carole A. Heilman and Fred Wang and Sandra E. Pike and S Stanley J. Korsmeyer and Kathy Siminovitch},
  journal={Journal of immunology},
  year={1986},
  volume={137 6},
  pages={2037-42}
}
Most continuous cell lines derived by EBV immortalization of peripheral blood cells are composed of phenotypically mature B lymphocytes, and secrete Ig. Occasionally, EBV-immortalized cell lines have failed to secrete Ig. Expansion and characterization of one of these EBV-induced cell lines, VDS-O, showed that in addition to a lack of Ig secretion, surface and intracytoplasmic Ig were absent. Cell surface phenotyping revealed that VDS-O belongs to the B cell lineage, because it expresses the B… CONTINUE READING