Epstein-Barr virus-coded BHRF 1 protein , a viral homologue of Bcl-2 , protects human B cells from programmed cell death

@inproceedings{Henderson2005EpsteinBarrVB,
  title={Epstein-Barr virus-coded BHRF 1 protein , a viral homologue of Bcl-2 , protects human B cells from programmed cell death},
  author={S J. Hodges. B. Henderson and David Huen and Martin Rowe and Chris Dawson and GERALD JOHNSONt and Alan B. Rickinson},
  year={2005}
}
Epstein-Barr virus, a human herpesvirus that persists within the B-lymphoid system, can enhanc the survival potential of latently infected B cells in vitro through up-regation of the cellular survival protein Bcl-2. The possiblilty that an analogous effect is operative in lytically infected cells was sugested by the observation of distant sequence homolgy between an Epstein-Barr virus-coded early lytic cyde protein, BHERF1, and Bcl-2. Here we show by gene trausfer that BHERF1 resembles Bcd-2… CONTINUE READING
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