Epstein-Barr virus and other candidate viruses in the pathogenesis of Hodgkin's disease.

@article{Jarrett1999EpsteinBarrVA,
  title={Epstein-Barr virus and other candidate viruses in the pathogenesis of Hodgkin's disease.},
  author={Ruth F. Jarrett and J Mackenzie},
  journal={Seminars in hematology},
  year={1999},
  volume={36 3},
  pages={260-9}
}
The epidemiologic and clinicopathologic features of Hodgkin's disease (HD) suggest that an infectious agent is involved in the etiology. Over the last 12 years, evidence has accumulated suggesting that Epstein-Barr virus (EBV) is associated with a proportion of cases: EBV genomes are present in Reed-Sternberg (HRS) cells and viral proteins including LMP1, which has oncogenic potential, are expressed. HD has a complex epidemiology and EBV-associated cases are not randomly distributed. Disease… CONTINUE READING

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