Epstein-Barr virus and multiple sclerosis.

@article{Robinson2022EpsteinBarrVA,
  title={Epstein-Barr virus and multiple sclerosis.},
  author={William H. Robinson and Lawrence Steinman},
  journal={Science},
  year={2022},
  pages={
          eabm7930
        }
}
Infection with Epstein-Barr virus is the trigger for the development of multiple sclerosis. 
Epstein-Barr virus as a driver of multiple sclerosis
  • L. Sollid
  • Medicine, Psychology
    Science Immunology
  • 2022
TLDR
If EBV is a “driver” of MS by inducing antiviral immunity with associated autoimmunity, elimination of EBV may be a rational therapy for MS.
Herpesvirus Vaccines
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This commentary highlights the involvement of age-associated B cells, a B cell population defined as CD19+CD11c+CD21−T-bet+, in the process of EBV-triggered autoimmunity, and modifies ABCs, so as to function pathogenically in autoimmune diseases Apart from EBV elimination, targeting of ABCs may also bring therapeutic benefits to autoimmune patients.
Immune Privilege Furnishes a Niche for Latent Infection
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This review summarises how immune privilege in the CNS may be permissive for latent infection and allow the eye and the brain to act as a reservoir of pathogens which often remain undetected for the lifetime of the host but in states of immune deficiency may be activated to cause sight- and life-threatening inflammation.
Role of Helical Structure in MBP Immunodominant Peptides for Efficient IgM Antibody Recognition in Multiple Sclerosis
TLDR
This work investigates the importance of the helical structure in antibody recognition by MBP peptides of different lengths and synthesized the peptide MBP (81–106) and observed that its elongation at both N- and C-termini improves IgM antibody recognition in SP-ELISA, but destabilizes the helicals structure.
The Human Myelin Proteome and Sub-Metalloproteome Interaction Map: Relevance to Myelin-Related Neurological Diseases
TLDR
The presented PPI dataset could provide a useful resource to the scientific community to further the understanding of human myelin biology and serve as a basis for future studies of myelin-related neurological diseases and particular autoimmune diseases such as multiple sclerosis where myelin epitopes are implicated.
The Potential for EBV Vaccines to Prevent Multiple Sclerosis
TLDR
Assessment of vaccine efficacy with MS being a delayed consequence of EBV infection with the average age of onset being approximately 30 years of age represents multiple challenges.

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The presence of ANO2 reactivity associates with a high MS risk, in particular together with HLA risk variants and high EBNA1 antibody titers, which is considered a strong argument for its relevance in MS ethiopathogenesis.
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Examination of the expression of LMP1 in the context of EBNA-1 may interact to increase immune dysregulation that leads to pathogenic, autoantigen-specific lupus inflammation, suggesting that a combination of EBV and genetic factors may be required to drive l upus-associated renal disease.
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Autoantibodies from patients with systemic lupus erythematosus bind a shared sequence of SmD and Epstein‐Barr virus‐encoded nuclear antigen EBNA I
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It is shown that whereas EBV stands out as the only infectious agent that can explain many of the key features of MS epidemiology, by itself the link between EBV and MS cannot explain the decline in risk among migrants from high to low MS prevalence areas, which implies that either EBV strains in low‐risk areas have less propensity to cause MS, or that other infectious or noninfectious factors modify the host response to EBV or otherwise contribute to determine MS risk.
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Rabbit central nervous system tissue taken from these rabbits had a histologic picture reminiscent of experimental allergic encephalomyelitis, indicating that viral infection may trigger the production of antibodies and mononuclear cells that cross-react with self proteins by a mechanism termed molecular mimicry.
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