Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus.

  title={Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus.},
  author={Brian D Poole and Robert Hal Scofield and John Barker Harley and Judith A James},
  volume={39 1},
Systemic lupus erythematosus (SLE or lupus) is a complex disease with a multifactoral etiology, with genetic, hormonal, and environmental influences. Molecular mimicry as a result of viral infection may contribute to the development of lupus. The pattern of autoantibody development in lupus is consistent with initiation through molecular mimicry, as the initial autoantigenic epitopes that have been observed are limited and cross-reactive with viral proteins. Autoantibody specificity may then… CONTINUE READING