Epstein-Barr virus DNA load in chronic lymphocytic leukemia is an independent predictor of clinical course and survival

@inproceedings{Visco2015EpsteinBarrVD,
  title={Epstein-Barr virus DNA load in chronic lymphocytic leukemia is an independent predictor of clinical course and survival},
  author={Carlo Visco and Erika Falisi and KEN. H. YOUNG and Michela Pascarella and Omar Perbellini and Giuseppe Carli and Elisabetta Novella and Davide Rossi and Ilaria Giaretta and Chiara Cavallini and Maria Teresa Scupoli and Anita De Rossi and E S D'amore and Mario Rassu and Gianluca Gaidano and Giovanni Pizzolo and Achille Ambrosetti and Francesco Rodeghiero},
  booktitle={Oncotarget},
  year={2015}
}
The relation between Epstein-Barr virus (EBV) DNA load and clinical course of patients with chronic lymphocytic leukemia (CLL) is unknown. We assessed EBV DNA load by quantitative PCR at CLL presentation in mononuclear cells (MNC) of 220 prospective patients that were enrolled and followed-up in two major Institutions. In 20 patients EBV DNA load was also assessed on plasma samples. Forty-one age-matched healthy subjects were tested for EBV DNA load on MNC. Findings were validated in an… CONTINUE READING