Epstein-Barr virus BZLF1 trans activator induces the promoter of a cellular cognate gene, c-fos.

@article{Flemington1990EpsteinBarrVB,
  title={Epstein-Barr virus BZLF1 trans activator induces the promoter of a cellular cognate gene, c-fos.},
  author={Erik K. Flemington and Samuel H Speck},
  journal={Journal of virology},
  year={1990},
  volume={64 9},
  pages={4549-52}
}
The Epstein-Barr virus BZLF1 gene product ZEBRA is a DNA-binding protein that is partially homologous to c-Fos, binds specifically to AP-1 sites, and can induce the lytic cycle in latently infected B lymphocytes. Induction of the viral lytic cycle can also be achieved by treatment with the phorbol ester 12-O-tetrade-canoylphorbol-13-acetate, a reagent which activates gene expression in part through AP-1 (Jun/Fos). In this article the interrelationship between ZEBRA and AP-1 is extended by the… CONTINUE READING
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