Epstein-Barr virus BGLF4 kinase downregulates NF-κB transactivation through phosphorylation of coactivator UXT.

@article{Chang2012EpsteinBarrVB,
  title={Epstein-Barr virus BGLF4 kinase downregulates NF-κB transactivation through phosphorylation of coactivator UXT.},
  author={Ling-Shih Chang and Jiin-Tarng Wang and Shin-Lian Doong and Chung-Pei Lee and C J Chang and Ching-Hwa Tsai and S Yeh and Ching-Yueh Hsieh and M Chen},
  journal={Journal of virology},
  year={2012},
  volume={86 22},
  pages={12176-86}
}
Epstein-Barr virus (EBV) BGLF4 is a member of the conserved herpesvirus kinases that regulate multiple cellular and viral substrates and play an important role in the viral lytic cycles. BGLF4 has been found to phosphorylate several cellular and viral transcription factors, modulate their activities, and regulate downstream events. In this study, we identify an NF-κB coactivator, UXT, as a substrate of BGLF4. BGLF4 downregulates not only NF-κB transactivation in reporter assays in response to… CONTINUE READING

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