Epstein-Barr virus (EBV)-associated lymphoid proliferations, a 2018 update.

@article{Rezk2018EpsteinBarrV,
  title={Epstein-Barr virus (EBV)-associated lymphoid proliferations, a 2018 update.},
  author={Sherif A Rezk and Xiaohui Zhao and Lawrence Martin Weiss},
  journal={Human pathology},
  year={2018},
  volume={79},
  pages={
          18-41
        }
}
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42 Citations
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42 Citations

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EBV-Associated Lymphoproliferative Disorders: Update in Classification.
The Impact of Epstein Barr-Virus on Therapeutic Options of Lymphoma
TLDR
Future trends are thought to differ based on more better understanding of biology of EBV and to target such mechanisms that counteract or interfere with its pathogenesis including activation of apoptotic pathways or activating immunosuppression mechanisms.
EBV+ high‐grade B cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a multi‐institutional study
It is unknown whether Epstein–Barr virus (EBV) infection can occur in high‐grade B cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, also known as double‐ or triple‐hit lymphoma (DHL/THL).
An oncogenic Epstein Barr virus developing diseases and cancer in human
TLDR
The present paper deals with the study of Epstein Barr virus causing several diseases including cancer in human, which ranges from infectious mononucleosis to the cancerous Burkitt’s lymphoma.
Chronic active Epstein-Barr virus infection progresses to aggressive NK cell leukemia with a poor prognosis.
TLDR
The detailed diagnostic and differential diagnostic process of EBV infection was shown and a 20-year-old male patient with repeated infectious mononucleosis (IM)-like symptoms such as high fever, splenomegaly, lymphadenopathy for more than two years was reported.
Epstein - Barr virus association with plasma cell neoplasms.
TLDR
Evaluated data shows that EBV was negative in all plasma cell myeloma cases in immunocompetent patients and has an overall low association with the different plasma cell neoplasms in the immunoccompetent setting.
Molecular Properties and Therapeutic Targeting of the EBV-Encoded Receptor BILF1
TLDR
This review summarizes the epidemiology of EBV-associated malignancies, their current standard-of-care, EBv-specific therapeutics in development, GPCRs and their druggability, and most importantly consolidates the findings of over 15 years of research on BILF1 in the context ofEBV-specific drug development.
Reactivation of Epstein–Barr Virus Presenting as Massive Splenomegaly after Initiation of Golimumab Treatment
TLDR
A 71-year-old female with seronegative rheumatoid arthritis who presented with massive splenomegaly, pancytopenia, and positivization of antibodies against double-stranded deoxyribonucleic acid (dsDNA) after initiation of the anti-tumor necrosis factor (TNF) golimumab is reported.
Epstein-Barr virus incidental expression in bone marrow cells: a study of 230 consecutive bone marrow biopsy samples.
The Morphologic Features of Primary Epstein-Barr Virus Infection in the Gastrointestinal Tract
TLDR
It was found that there was no difference in pathologic findings in Immunocompetent and immunocompromised patients, which ranged from essentially subtle to severe mucosal architectural distortion with prominent lymphoid aggregates, and most cases showed either focal or diffuse lymphocytic infiltration.
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References

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TLDR
Intriguingly, the three main types of EBV-associated B-cell lymphoma — that is, Burkitt lymphoma, Hodgkin lymphoma and post-transplant lymphomas — seem to derive from germinal-centre B cells or atypical survivors of the germinalscentre reaction in most, if not all, cases, indicating that EBV -infected germinAL-cent centre B cells are at particular risk for malignant transformation.
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