Epstein-Barr virus/C3d receptor (CR2, CD21) activated by its extracellular ligands regulates pp105 phosphorylation through two distinct pathways.

@article{Bouillie1995EpsteinBarrVR,
  title={Epstein-Barr virus/C3d receptor (CR2, CD21) activated by its extracellular ligands regulates pp105 phosphorylation through two distinct pathways.},
  author={Sylvie Bouillie and Monique Barel and Pascal Dran{\'e} and Bruno Cassinat and Michelle Balbo and V. Michael Holers and Raymond Frade},
  journal={European journal of immunology},
  year={1995},
  volume={25 9},
  pages={2661-7}
}
We previously demonstrated that human C3d or pep16, a 16-amino acid synthetic peptide derived from human C3d, induced in vivo and in vitro tyrosine phosphorylation of pp105, an intracellular component found only in human cells that express CR2 at their surface. To determine the contribution of CR2 molecules to this enzymatic regulation, we first analyzed whether activation of CR2 by other extracellular CR2 ligands could trigger such regulation in cell extracts. Subsequently, we used cell… CONTINUE READING