Epstein-Barr Viruses (EBVs) Deficient in EBV-Encoded RNAs Have Higher Levels of Latent Membrane Protein 2 RNA Expression in Lymphoblastoid Cell Lines and Efficiently Establish Persistent Infections in Humanized Mice

@inproceedings{Gregorovic2015EpsteinBarrV,
  title={Epstein-Barr Viruses (EBVs) Deficient in EBV-Encoded RNAs Have Higher Levels of Latent Membrane Protein 2 RNA Expression in Lymphoblastoid Cell Lines and Efficiently Establish Persistent Infections in Humanized Mice},
  author={Goran Gregorovic and Elizabeth A. Boulden and Rachel Bosshard and Claudio Elgueta Karstegl and Rebecca L Skalsky and Bryan R. Cullen and Cornelia Gujer and Patrick C R{\"a}mer and Christian M{\"u}nz and Paul J. Farrell and Richard Longnecker},
  booktitle={Journal of virology},
  year={2015}
}
Functions of Epstein-Barr virus (EBV)-encoded RNAs (EBERs) were tested in lymphoblastoid cell lines containing EBER mutants of EBV. Binding of EBER1 to ribosomal protein L22 (RPL22) was confirmed. Deletion of EBER1 or EBER2 correlated with increased levels of cytoplasmic EBV LMP2 RNA and with small effects on specific cellular microRNA (miRNA) levels, but protein levels of LMP1 and LMP2A were not affected. Wild-type EBV and EBER deletion EBV had approximately equal abilities to infect… CONTINUE READING
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