Epstein-Barr Virus Transformation of Human Lymphoblastoid Cells from Patients with Fragile X Syndrome Induces Variable Changes on CGG Repeats Size and Promoter Methylation


Background: Our understanding of fragile X syndrome can be improved by reversing the expression of the silenced fragile X mental retardation 1 (FMR1) gene in immortalized cells from these patients. Epstein-Barr virus (EBV) infection has been extensively used to transform B cells into a permanent lymphoblastoid cell line. Methods: We immortalized B… (More)
DOI: 10.1007/BF03260033


4 Figures and Tables