Epstein-Barr Virus MicroRNA Expression Increases Aggressiveness of Solid Malignancies

@inproceedings{Pandya2015EpsteinBarrVM,
  title={Epstein-Barr Virus MicroRNA Expression Increases Aggressiveness of Solid Malignancies},
  author={Deep Pandya and Marisa Mariani and Shiquan He and Mirko Andreoli and Manuela Spennato and Candice C Dowell-Martino and Paul N. Fiedler and Cristiano Ferlini and S{\'e}bastien Pfeffer},
  booktitle={PloS one},
  year={2015}
}
The Cancer Genome Atlas (TCGA) microRNA (miRNA) initiative has revealed a pivotal role for miRNAs in cancer. Utilizing the TCGA raw data, we performed the first mapping of viral miRNA sequences within cancer and adjacent normal tissues. Results were integrated with TCGA RNA-seq to link the expression of viral miRNAs to the phenotype. Using clinical data and viral miRNA mapping results we also performed outcome analysis. Three lines of evidence lend credence to an active role of viral miRNAs in… CONTINUE READING

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