Epstein-Barr Virus Latent Membrane Protein 2A (LMP2A) enhances IL-10 production through the activation of Bruton's tyrosine kinase and STAT3.

@article{Incrocci2017EpsteinBarrVL,
  title={Epstein-Barr Virus Latent Membrane Protein 2A (LMP2A) enhances IL-10 production through the activation of Bruton's tyrosine kinase and STAT3.},
  author={Ryan Incrocci and Levi Barse and Amanda L Stone and Sai Vagvala and Michael Montesano and Vijay Subramaniam and Michelle Swanson-Mungerson},
  journal={Virology},
  year={2017},
  volume={500},
  pages={
          96-102
        }
}
Previous data demonstrate that Epstein-Barr Virus Latent Membrane Protein 2A (LMP2A) enhances IL-10 to promote the survival of LMP2A-expressing B cell lymphomas. Since STAT3 is an important regulator of IL-10 production, we hypothesized that LMP2A activates a signal transduction cascade that increases STAT3 phosphorylation to enhance IL-10. Using LMP2A-negative and -positive B cell lines, the data indicate that LMP2A requires the early signaling molecules of the Syk/RAS/PI3K pathway to increase… CONTINUE READING

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