Epstein-Barr Virus Infections: Biology, Pathogenesis, and Management

@article{Straus1993EpsteinBarrVI,
  title={Epstein-Barr Virus Infections: Biology, Pathogenesis, and Management},
  author={Stephen E. Straus and JE Cohen and Giovanna Tosato and Jeffery L Meier},
  journal={Annals of Internal Medicine},
  year={1993},
  volume={118},
  pages={45-58}
}
Dr. Stephen E. Straus (Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases [NIAID], National Institutes of Health [NIH], Bethesda, Maryland): Epstein-Barr virus (EBV) is a ubiquitous pathogen that has evolved an effective strategy for infection, persistence, and spread; EBV infection occurs in more than 90% of the population, most often without evident consequences [1, 2]. The clinical outcome of infection rests on the compromise… 
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References

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The early accurate diagnosis of EBV infection can be achieved by performing EBV-specific serology, detecting forEBV-determined nuclear antigen in tissues, establishing spontaneous lymphoid cell lines, and using molecular hybridization techniques for demonstrating the presence of viral genome in affected lesions.
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Serological investigations on 147 patients with Paul—Bunnell positive infectious mononucleosis from the general population found EBY antibody prevalence among patients' siblings was significantly lower than among age-matched controls, suggesting that cases of IM come from families with a lower than normal previous experience of the virus.
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TLDR
Two patients developed fever, interstitial pneumonitis, and pancytopenia associated with extremely high titers of antibody to replicative antigens of the Epstein-Barr virus and provide additional evidence that acyclovir may play a role in therapy for selected patients with Epstein-barr virus infection.
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TLDR
It is hypothesized that the defective lymphoproliferative control locus on the X chromosome results in unregulated cytotoxic lymphocytic responses to the Epstein-Barr virus; hence, severe hepatitis and virus-associated hemophagocytic syndrome occur with the infectious mononucleosis phenotype.
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TLDR
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TLDR
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TLDR
Proliferating B cell lesions developing in a series of immunosuppressed organ transplant recipients and patients with X-linked lymphoproliferative syndrome were examined for Epstein-Barr virus and cellular gene expression using immunocytochemistry and immunoblotting techniques, and results indicate that all the lesions examined were consistent with a latent, nonproductive type of infection.
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Results suggest that the latently EBV-infected host cells reside in a cellular compartment that can be destroyed by graft-versus-host reactivity, irradiation, or cytotoxic drugs, and Hemopoietic tissue is the most likely candidate.
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