Epstein-Barr Virus BGLF4 Kinase Retards Cellular S-Phase Progression and Induces Chromosomal Abnormality

  title={Epstein-Barr Virus BGLF4 Kinase Retards Cellular S-Phase Progression and Induces Chromosomal Abnormality},
  author={Yu-Hsin Chang and C. Lee and Mei-Tzu Su and Jiin-Tarng Wang and Jen-Yang Chen and Su-Fang Lin and Ching-Hwa Tsai and Min-Jei Hsieh and K. Takada and M. Chen},
  journal={PLoS ONE},
  • Yu-Hsin Chang, C. Lee, +7 authors M. Chen
  • Published 2012
  • Biology, Medicine
  • PLoS ONE
  • Epstein-Barr virus (EBV) induces an uncoordinated S-phase-like cellular environment coupled with multiple prophase-like events in cells replicating the virus. The EBV encoded Ser/Thr kinase BGLF4 has been shown to induce premature chromosome condensation through activation of condensin and topoisomerase II and reorganization of the nuclear lamina to facilitate the nuclear egress of nucleocapsids in a pathway mimicking Cdk1. However, the observation that RB is hyperphosphorylated in the presence… CONTINUE READING
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