Epstein–Barr virus promotes genomic instability in Burkitt's lymphoma

@article{Kamranvar2007EpsteinBarrVP,
  title={Epstein–Barr virus promotes genomic instability in Burkitt's lymphoma},
  author={Siamak Akbari Kamranvar and Bettina Gruhne and A. V{\'a}nyin{\'e} Sz{\'e}les and Maria Grazia Masucci},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={5115-5123}
}
Epstein–Barr virus (EBV) has been implicated in the pathogenesis of human malignancies but the mechanisms of oncogenesis remain largely unknown. Genomic instability and chromosomal aberrations are hallmarks of malignant transformation. We report that EBV carriage promotes genomic instability in Burkitt's lymphoma (BL). Cytogenetic analysis of EBV− and EBV+ BL lines and their sublines derived by EBV conversion or spontaneous loss of the viral genome revealed a significant increase in dicentric… CONTINUE READING
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