Epstein–Barr virus infection in humans: from harmless to life endangering virus–lymphocyte interactions

@article{Klein2007EpsteinBarrVI,
  title={Epstein–Barr virus infection in humans: from harmless to life endangering virus–lymphocyte interactions},
  author={Eva Klein and Lor{\'a}nd Levente Kis and George Klein},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={1297-1305}
}
After the primary infection, that may or may not cause infectious mononucleosis, the ubiquitous Epstein–Barr virus (EBV) is carried for lifetime. The great majority of adult humans are virus carriers. EBV was discovered in a B-cell lymphoma (Burkitt lymphoma). EBV infection in humans is the example for the power of immune surveillance against virus transformed, potentially malignant cells. Although the virus can transform B lymphocytes in vitro into proliferating lines, it induces malignancy… CONTINUE READING
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