Epstein–Barr virus‐associated T/natural killer‐cell lymphoproliferative disorders

@article{Park2014EpsteinBarrVT,
  title={Epstein–Barr virus‐associated T/natural killer‐cell lymphoproliferative disorders},
  author={Sanghui Park and Young Hyeh Ko},
  journal={The Journal of Dermatology},
  year={2014},
  volume={41}
}
  • Sanghui Park, Y. Ko
  • Published 1 January 2014
  • Medicine, Biology
  • The Journal of Dermatology
Primary infection with Epstein–Barr virus (EBV) is usually asymptomatic and, in a normal host, EBV remains latent in B cells after primary infection for the remainder of life. Uncommonly, EBV can infect T or natural killer (NK) cells in a person with a defect in innate immunity, and EBV infection can cause unique systemic lymphoproliferative diseases (LPD) of childhood. Primary infection in young children can be complicated by hemophagocytic lymphohistiocytosis or fulminant systemic T‐cell LPD… 
Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases
TLDR
The EBV-associated hemophagocytic lymphohistiocytosis (HLH), although not included in the WHO classification because it is a reactive, inflammatory disease, is included in this review because it can be life-threatening and may have overlapping features with other EBV+ T/NK LPDs.
Epstein-Barr Virus Type 2 Latently Infects T Cells, Inducing an Atypical Activation Characterized by Expression of Lymphotactic Cytokines
TLDR
The novel finding that EBV-2 infects T cells in culture will provide a model to understand the role EBV plays in the development of T-cell lymphomas and lay the foundation for further studies to elucidate the role of EBV in the pathogenesis of T -cell lymphoproliferative diseases.
Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification
TLDR
This article reviews the current evidence covering EBV-associated LPDs based on the 2016 classification of the World Health Organization and explains why it is important to understand their unique pathophysiology for correct diagnoses and optimal management.
EBV-positive T/NK lymphoproliferative diseases: analysis of prognostic factors for patients in China.
TLDR
It was observed that the high mortality rate of EBV + T/NK-LPD was mainly due to serious and fatal complications, and disease prognosis should be based on a comprehensive analysis of pathological and clinical data.
Chronic active EBV infection associated with NK cell lymphoma and hemophagocytic lymphohistiocytosis in a 27-year-old woman
TLDR
In the clinical setting of unexplained fever and liver injury, it is necessary to be aware of CAEBV, as well as its fatal complication such as EBV associated NK cell lymphoma and HLH.
EBV-Positive Lymphoproliferations of B- T- and NK-Cell Derivation in Non-Immunocompromised Hosts
TLDR
The definitions, morphology, pathogenesis, and evolving concepts of the various EBV-associated disorders including EBV+ diffuse large B-cell lymphoma, not otherwise specified,EBV+ mucocutaneous ulcer, DLBCL associated with chronic inflammation, fibrin-associatedDLBCL, lymphomatoid granulomatosis are reviewed.
Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia
TLDR
Unsupervised hierarchal clustering analyses of microarray data and gene ontology analysis revealed specific gene clusters and identified several candidate genes responsible for disease that can be used to discriminate each category of NK-LPD and NK-cell lymphoma/leukemia.
Comprehensive assessment of peripheral blood TCRβ repertoire in infectious mononucleosis and chronic active EBV infection patients
TLDR
This study fully characterized the diversity of peripheral blood TCRβ repertoire in IM and CAEBV patients and observed some disease-related preferences in TRBV/TRBJ usage and combinations, as well as lots of T cell clones shared by different groups involved in public T cell responses, which provide more detailed insights into the divergent disease evolution.
Epstein-Barr Virus Type 2 Infects T Cells and Induces B Cell Lymphomagenesis in Humanized Mice
TLDR
An EBV-2 humanized mouse model is developed, utilizing immunodeficient mice engrafted with human cord blood CD34+ stem cells, that establishes a latency III infection with evidence of ongoing viral reactivation in both B and T cells and efficiently induces lymphomagenesis in humanized mice.
CD30-Positive T-Cell Lymphoproliferative Disease of the Oral Mucosa in Children: A Manifestation of Epstein-Barr Virus-Associated T-Lymphoproliferative Disorder
  • M. Hong, Y. Ko
  • Medicine
    Journal of pathology and translational medicine
  • 2015
TLDR
Eosinophilic ulcer of the oral mucosa in children is a manifestation of EBV-positive T-cell LPD, and should therefore be distinguished from the disease in adults.
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