Epstein–Barr Virus MicroRNAs Are Evolutionarily Conserved and Differentially Expressed

@article{Cai2006EpsteinBarrVM,
  title={Epstein–Barr Virus MicroRNAs Are Evolutionarily Conserved and Differentially Expressed},
  author={Xuezhong Cai and Alexandra Schaefer and Shihua Lu and John P Bilello and Ronald C Desrosiers and Rachel Hood Edwards and Nancy Raab-Traub and Bryan R Cullen},
  journal={PLoS Pathogens},
  year={2006},
  volume={2},
  pages={281 - 297}
}
The pathogenic lymphocryptovirus Epstein-Barr virus (EBV) is shown to express at least 17 distinct microRNAs (miRNAs) in latently infected cells. These are arranged in two clusters: 14 miRNAs are located in the introns of the viral BART gene while three are located adjacent to BHRF1. The BART miRNAs are expressed at high levels in latently infected epithelial cells and at lower, albeit detectable, levels in B cells. In contrast to the tissue-specific expression pattern of the BART miRNAs, the… CONTINUE READING
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Epstein–Barr virus and its replication

  • E Kieff, AB Rickinson
  • 2001
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