Epstein – Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-κB pathway involving TNF receptor-associated factors

@article{Eliopoulos1997EpsteinB,
  title={Epstein – Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-κB pathway involving TNF receptor-associated factors},
  author={Aristides G. Eliopoulos and Maria Stack and Christopher Dawson and Kenneth M Kaye and Liz Hodgkin and Sim Sihota and Martin Rowe and Lawrence S Young},
  journal={Oncogene},
  year={1997},
  volume={14},
  pages={2899-2916}
}
Expression of the Epstein – Barr virus (EBV) transforming LMP1 in B cells activates the transcription factor NF-κB and induces phenotypic changes through two distinct domains in the cytoplasmic C-terminus of the protein. The aa 187 – 231 domain of LMP1, which is important for growth transformation, binds tumour necrosis factor (TNF) receptor associated… CONTINUE READING