EpsinR, a target for pyrenocine B, role in endogenous MHC‐II‐restricted antigen presentation

@article{Shishido2014EpsinRAT,
  title={EpsinR, a target for pyrenocine B, role in endogenous MHC‐II‐restricted antigen presentation},
  author={Tatsuya Shishido and Masami Hachisuka and Kai Ryuzaki and Y. Miura and A. Tanabe and Y. Tamura and Tomoe Kusayanagi and T. Takeuchi and S. Kamisuki and F. Sugawara and H. Sahara},
  journal={European Journal of Immunology},
  year={2014},
  volume={44}
}
While the presentation mechanism of antigenic peptides derived from exogenous proteins by MHC class II molecules is well understood, relatively little is known about the presentation mechanism of endogenous MHC class II‐restricted antigens. We therefore screened a chemical library of 200 compounds derived from natural products to identify inhibitors of the presentation of endogenous MHC class II‐restricted antigens. We found that pyrenocine B, a compound derived from the fungus Pyrenochaeta… Expand
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