Epsin potentiates Notch pathway activity in Drosophila and C. elegans.

  title={Epsin potentiates Notch pathway activity in Drosophila and C. elegans.},
  author={Xiaolin Tian and Dave Hansen and Tim Schedl and James B Skeath},
  volume={131 23},
Endocytosis and trafficking within the endocytosis pathway are known to modulate the activity of different signaling pathways. Epsins promote endocytosis and are postulated to target specific proteins for regulated endocytosis. Here, we present a functional link between the Notch pathway and epsins. We identify the Drosophila ortholog of epsin, liquid facets (lqf), as an inhibitor of cardioblast development in a genetic screen for mutants that affect heart development. We find that lqf inhibits… CONTINUE READING

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